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some of the study period preceded the approval of semaglutide and tirzepatide to treat obesity

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10.1093/hmg/ddr139 91 MarinoM.GalluzzoP.AscenziP
[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Courcoulas A.P., Christian N.J., Belle S.H., et al

While joint pain relief is not an FDA-approved indication for GLP-1 medications, emerging clinical observations and patient reports have prompted investigation into potential musculoskeletal benefits

It enrolled adults with a body mass index of 30 or greater, or 27 or greater with at least one weight-related comorbidity, and randomized them across multiple retatrutide dose arms (1 mg, 4 mg, 8 mg, and 12 mg weekly) versus placebo
