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202201011395 to X.L

The Lancet, 390 (10103): 16641675

GLP-1RAs mimic endogenous incretin hormones that regulate insulin secretion, glucose homeostasis, gastric emptying, and appetite control

The efficacy of tirzepatide in attaining a 1520% reduction in weight while preserving gastrointestinal tolerability illustrates that this equilibrium is attainable, although necessitating advanced drug design (Tuttle et al

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor
doi: 10.1210/jc.2003-032001
