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Various studies have now shown that GLP-1 and GLP-1RA drugs directly promote M2 phase while inhibiting M1 phase, this ties back to the reductions in TNF-a and IL-6 mentioned earlier, along with various other inflammatory cytokines

Molecule of the Month: GLP-1 Receptor Agonists Popular and effective drugs for the treatment of obesity and diabetes Improving on a lizard toxin Small molecule mimics Exploring the Structure Compare how peptide-based and small molecule drugs bind to the GLP-1 receptor While peptide-based GLP-1 receptor agonists all bind to the GLP-1 receptor in similar ways, the small molecule orforglipron is much smaller with far fewer interactions

Although the aforementioned studies indicate that central mechanisms modulate the ability of GLP-1R agonists to reduce alcohol intake, other mechanisms such as the gut microbiota may participate

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Safety vigilance, thoughtful patient selection, and integration with behavioural care are the practical requirements for translating trial efficacy into real-world benefit