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15 Two large, randomized control trials (RCTs) investigating liraglutide and semaglutide also suggested worsening retinopathy as an adverse effect of GLP-1RA use

Manufacturing standards matter significantly

The question of the presence and localization of GLP-1 receptors in the heart, as well as species-specific expression patterns herein, has been ongoing since the realization that the GLP-1 RAs invariably increase heart rate in humans