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This suggests that systemic endothelial dysfunction may be a primary factor in the development of systemic hypertension and its pathological consequences, such as increased left ventricular wall stress, hypertrophy, diastolic dysfunction, and HFpEF [22]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Borges M., Sampaio F., Costa J., Freitas P., Matias Dias C., Gaio V., Conde V., Figueira D., Pinheiro B., Silva Miguel L
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Husain et al., 2019)
