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Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage

(PubMed) In a study with 667 adults having high BMI, those on semaglutide 50 mg achieved bigger weight reductions (85%, 69%, and 34% for 5%, 10%, and 20% respectively) compared to those on placebo (26%, 12%, and 3%)

We demonstrated that in GLUTag cells, a high glucose level with L-glutamine stimulates GLP-1 secretion through a synergistic effect rather than cAMP amplification, and that a high glucose level potentiates L-glutamine-Gs activation in GLP-1 secretion

For comparison, our semaglutide program starts at $249/month on a 6-month plan