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Methods Target trial emulation We conducted an observational study emulating a set of eight parallel, pragmatic, active comparator, new user target trials using US Department of Veterans Affairs electronic health records

Pfizer terminated lotiglipron in October 2023 due to dose-dependent liver enzyme elevations, and subsequently discontinued danuglipron in April 2025 after a single case of potential drug-induced liver injury was identified in a dose-optimization study

Liraglutide, which has been approved for reducing the risk of T2MD, has also been found to reduce the risk of major cardiovascular events in adults with established CVDs ( Table 1 Classification of GLP-1RAs

Interleukin-6 (IL-6) is a myokine produced in response to physical activity

Injectable drugs like GLP-1 receptor agonists are powerful tools for weight loss, but they need to be used correctly and monitored carefully by a healthcare provider to ensure safety

Garcia-Webb also explains Trulicity and Ozempics effect on the brain: They often affect the reward circuitry in the brain, so food is less entertaining