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51 Activated T cells in the TME are crucial for tumor cell elimination, but resistance can develop through upregulation of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), lymphocyte activation gene 3 (LAG-3), T cell immunoreceptor with Ig and ITIM domains (TIGIT), and T cell immunoglobulin and mucin-domain containing-3 (TIM-3) on T cells