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It also creates inflammation, which is linked to obesity (3, 4, 5, 6)
GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(/) mice
Mechanisms identified include: increased cardiac utilization of ketones increased autophagy (recycling of intracellular components)l decreased inflammation & oxidative stress improved mitochondrial function decreased intracellular Ca & Na overload decreased fibrosis improved myocardial diastolic function decrease myocardial hypertrophy Figure: Mechanism of action of action of SGLT-2 inhibitors in the kidney
Bariatric surgery and obesity management 4
Most people who take Wegovy are still able to drink small amounts of alcohol
Novo Nordisk created Ozempic after years of testing and developing GLP-1 drugs
