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Psychiatry 66, 6372

Evidence base : Semaglutide has been studied in large, randomized controlled trials involving tens of thousands of patients, with well-established safety and efficacy profiles

Native oxyntomodulin has significant glucoregulatory effects independent of weight loss in obese humans with and without type 2 diabetes

77 Overall, GLP-1 RAs appear more relevant in HFpEF, particularly with concomitant obesity, where BP lowering contributes to broader cardiometabolic benefits rather than a direct heart failure therapy

One of the participants, Caroline M

Missing doses or inconsistent timing has a more pronounced effect on efficacy because the three-receptor system requires consistent activation to maintain its synergistic benefits
