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L.ChallaS.et al (2018)

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Interpretation of the cardiovascular actions of native GLP-1 requires consideration that carboxy- terminal fragments, such as GLP-1(936) and GLP-1(2836), the latter generated from neutral endopeptidase-mediated proteolytic cleavage, retain biological activity in the cardiovascular system through mechanisms independent of the canonical GLP-1R

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A study on mice treated with methionine-choline-deficient diets showed that four-week infusion of liraglutide at a dose of 570 mg/kg/day was associated with the anti-inflammatory effect observed as a reduction in the accumulation of M1 macrophages

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