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14 In contrast, GLP-1 RAs have primarily been associated with gastrointestinal side effects and have demonstrated more favorable psychiatric and cardiovascular safety profiles

It originates from the preproglucagon precursor, which undergoes enzymatic processing within intestinal L-cells, ultimately giving rise to GLP-1(1-37) and GLP-1(7-36) amide or GLP-1(7-37) peptide variants

Current evidence from large-scale randomized controlled trials, observational studies, and real-world data presents a complex picture of this relationship
Harlan Krumholz, a cardiologist at Yale University and Yale New Haven Hospital, told CNN by email

Protein-Rich Meals: Enhancing GLP-1 Levels Pro Tip: Protein intake can increase GLP-1 levels, helping stabilize blood sugar and reduce hunger