glp-1 non responders Not losing weight on Ozempic, Wegovy or Mounjaro? You're not the only one. weight loss medications can be incredibly helpful for some people. But they don't work the same way for Doctor, I'm not losing weight
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Should I stop tirzepatide if I am gaining weight
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Insulin resistance (IR) occurs early in the course of PCOS and is frequently present even in the absence of obesity, accounting for 60-80% of women with PCOS (26)

Body fat serves as insulation, helping to maintain core body temperature and reduce heat loss to the environment

If a patient stops the medication, diabetes will relapse (if it was controlled, not cured) and weight will likely be regained, as evidenced by trials where cessation led to weight regain trends
J Cell Physiol 230:30093018 Yu J, Shi YC, Ping F, Li W, Zhang HB, He SL, Zhao Y, Xu LL, Li YX (2021) Liraglutide inhibits osteoclastogenesis and improves bone loss by downregulating Trem2 in female type 1 diabetic mice: findings from transcriptomics
