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Similar content being viewed by others Introduction Preclinical research has further bolstered the notion of Parkinsons disease (PD) modification following subthalamic nucleus deep-brain stimulation (STN-DBS) through neural mechanisms such as increased survival of dopaminergic nigral neurons, increased brain-derived neurotrophic factor (BDNF) production, increased synaptic remodeling, dampened neuroinflammation, and decreased glutamate excitotoxicity 1,2

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