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These pharmacological differences highlight the challenge of pooling these agents together

Both GIP and GLP-1 are rapidly metabolised after their secretion via the enzyme dipeptidyl peptidase (DPP-4)

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Both compounds are developed by Eli Lilly, both target GLP-1 and GIP receptors, but Retatrutide adds a third receptor glucagon creating a triple agonist with superior weight loss results in clinical trials

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Combined ActRII inhibition and GLP-1 receptor agonism improves circulating markers of adipose inflammation and function Next, we determined if the changes in body composition induced by ActRII inhibition were associated with improved metabolic parameters, including blood glucose, insulin, and circulating adipokines and cytokines