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Clinical Evidence for GLP-1 Therapy and Weight Management Clinical trials (STEP 14, SUSTAIN trials) demonstrate that GLP-1 receptor agonists reduce body weight, improve glycemic control, and may lower cardiovascular risk in adults with overweight, obesity, or type 2 diabetes

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These observations imply that leptin reduction not only may be an effective therapy for weight loss but also may have other applications in reversing liver fibrosis

Glucagon-like peptide-1 modulates RAW264.7 macrophage polarization by interfering with the JNK/STAT3 signaling pathway

As expected, Hld Se enhanced GLP-1 secretion in the enteroid model (Fig