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Target maintenance doses: Based on clinical data, 812 mg weekly will likely represent the effective therapeutic range for obesity management

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Neurobiol Aging (2012) 33(2):26576

These medications carry a boxed warning regarding thyroid C-cell tumor risk observed in rodent studies and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

While these findings align with mechanisms relevant to aging biology, they do not establish that GLP-1 therapies directly modify intrinsic aging processes