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Less profound lowering effects of repeated administration GLP-1 RAs on alcohol intake has also been observed in rodents (Vallof et al., 2016)

LEADER Trial The renal outcome in this trial was a composite of new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal disease, or death due to renal disease

however, severe or bloody diarrhea, diarrhea lasting longer than 10 days after dose stabilization, or diarrhea accompanied by fever or abdominal pain warrants immediate medical evaluation

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Multiple studies have shown that GLP-1s can reduce ALT levels