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For instance, in addition to being derived from a human protein, the putative promiscuous T cell epitope found in teriparatide is highly cross-conserved with epitopes found in other prevalent human proteins, indicating that this promiscuous HLA binding region is likely to be tolerated by the human immune system, if not actively tolerogenic (Jawa et al., 2020)

sin embargo, los estudios antes citados no han evidenciado que el control estricto de la glucosa disminuye la mortalidad cardiovascular, solo han confirmado reduccin de la incidencia de infartos de miocardio

This review emphasizes the importance of regular potassium monitoring, the potential benefits of combining therapies such as sodium-glucose cotransporter 2 (SGLT2) inhibitors with RAASi to reduce the risk of hyperkalemia, and the emergence of the newer non-steroidal MRA (nsMRA), finerenone, which may have a lower risk of hyperkalemia

In 2018 Zheng and colleagues compared the efficacy of SGLT-2i, GLP-1 agonists, and DPP4i on mortality and cardiovascular end points using a network meta-analysis of 236 trials with 176 310 participants, finding that SGLT-2 inhibitors were associated with reduction in all MIs [HR 0.86 (95% CI 0.770.97)] and nonfatal MIs [HR 0.84 (95% CI 0.720.98)] compared with the control groups (Zheng et al., 2018)