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Dual- and triple action approaches which simultaneously target multiple pathways, for example, GLP1R/GIP (tirzepatide), GLP1R/GIP/glucagon (retatrutide) or amylin/GLP1R (CagriSemra) appear more potent and may push weight reduction to the mid-20% range and possibly beyond, while oral options seek to deliver levels of efficacy seen with injectables

Since treatment of obesity as a chronic disease would require long-term AOM use in many individuals, the cost-effectiveness of this approach has yet to be established and such an approach, while clinically recommended, may potentially put a strain on health systems

With new approvals for cardiovascular risk reduction and OSA, GLP1s are reshaping treatment paradigms across comorbid conditions and gaining traction with a broader set of providers