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Similarly, reduced levels of leptin a hormone produced by fat cells that signals satiety and supports metabolic function may in some individuals dampen thermogenic activity

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The enhanced mobility resulting from weight loss can also improve mood, social interactions, and overall well-being

In addition, FFA can interact with various other cytokines, such as hepatocyte nuclear factor 4- (HNF-4), leading to overall changes in signaling pathways that regulate metabolism and stress (58)