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This multicenter, double-blind, placebo-controlled trial enrolled people with NAFLD with liver fat content at or above 10% by MRI-PDFF, a FibroScan liver stiffness measure below 10 kPa, alanine aminotransferase (ALT) at or below 75 IU/L, and no diabetes or non-insulin-dependent diabetes with A1C below 9.5%

When patients increase from 0.25 mg to 0.5 mg weekly (or equivalent oral doses), the GI tract is exposed to stronger receptor activation

Terminal dUTP Nick End-labeling Staining Assay Assay Terminal dUTP nick end-labeling (TUNEL) staining assay was performed on H9c2 cells by using an in situ cell death detection kit (Roche Diagnostics) to evaluate cell apoptosis ( 5 cells/well) overnight before treatment with various agents in serum-free medium condition

However, its impact extends beyond glucose metabolism and includes effects on gastrointestinal physiology and possibly the immune response

Front Surg 9 , 918272 (2022)

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