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In the subgroup analyses, human GLP-1 RAs, but not nonhuman GLP-1 RAs, reduced the risk of MACE in patients with HF (p interaction = 0.11)

DPP-4 inhibitors were introduced for the treatment of type 2 diabetes in 2006
They modulate central neural pathways and peripheral metabolic processes, providing cardiometabolic benefits beyond weight reduction

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