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People on the highest dose of retatrutide dropped more than 17% of their body weight, on average, after 24 weeks, and progressed to an average 24% weight loss by the end of 48 weeks, the researchers found

A formal Data Sharing Agreement may be required between respective organisations once release of the data are approved and before data can be released

Cross-reactivity, the phenomenon where a test antibody binds to an unintended molecule, requires structural similarity between the intended target and the unintended compound

Statements Author contributions PV, JM, GP, and JDR: bibliographic search, writing, review and/or revision of the manuscript

Supportive care during the first month includes consistent hydration (measure intake with a water bottle), electrolyte supplementation with a daily electrolyte drink or capsules, consistent sleep schedule, and over-the-counter pain relief if needed

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