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While findings suggest a favorable therapeutic role and safety profile of GLP-1 RAs in managing overweight and obesity in IBD patients, limitations related to retrospective designs, small sample sizes, and potential risk of publication bias in most included studies underscore the need for larger prospective studies and randomized controlled trials

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Study and results: The SELECT trial was a multicenter, double-blind, randomized, placebo-controlled, event-driven superiority trial, conducted at 804 clinical sites in 41 countries