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Constipation On the opposite end, constipation affected 24.2% of semaglutide 2.4 mg users versus 11.1% on placebo in the STEP trials

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In fact, pasteurized Akkermansia supplementation reduced plasma insulin level markers by about 30% compared to a placebo and insulin sensitivity indices by more than 10%

Yusta B, Baggio LL, Estall JL, Koehler JA, Holland DP, Li H, Pipeleers D, Ling Z, and Drucker DJ

Neither option is universally superior for all individuals

Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice