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Dipeptidyl peptidase-4 (DPP-4), also known as CD26, is widely expressed in the epidermis and on multiple immune cell subtypes, and preclinical studies demonstrating cutaneous vasculitis in non-human primates with some, but not all, DPP-4 inhibitors [20], has heightened awareness of the potential consequences of DPP-4 inhibition on the skin

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84 , 85 Moreover, acute hyperglycaemia can lead to decreased gastric emptying