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doi: 10.1074/jbc.M103362200

Milliken BT, Elfers C, Chepurny OG, Chichura KS, Sweet IR, Borner T, et al

Additionally, a potential synergistic mechanism may exist between SGLT2 inhibitors and GLP-1RAs in the management of NASH [42]

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By activating additional receptors, dual and triple agonists can tap into a broader set of levers at once, offering the chance for greater weight reduction, improved glycemic control, and (possibly) fewer side effects compared to GLP-1 monotherapy