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Severe caloric restriction below 1,000 to 1,200 calories daily triggers an aggressive metabolic conservation response that can halt weight loss even in the presence of a large theoretical calorie deficit

Store vials upright to minimize the air-liquid interface, which can accelerate degradation

Lower doses are often sufficient for the final stretch and for maintenance

Creates a feeling of fullness, preventing overeating

Managing Side Effects Start at the lowest dose and titrate slowly Eat smaller, more frequent meals Avoid high-fat or greasy foods during titration Stay well hydrated Consider timing injections to minimize impact on daily activities Retatrutide vs Tirzepatide: Muscle Loss Concerns Losing muscle along with fat is a real concern with any rapid weight loss

However, trials specifically examining the effect of antihyperglycemic treatment on CV events in older populations are lacking