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Description
This article reports the weight loss efficacy of CagriSema (cagrilintide, an amylin analogue, in combination with semaglutide, a GLP1 analogue) in adults with overweight or obesity

From 2020 to 2022, prescriptions for these medications increased by 300%

Nutritional signals rapidly activate oligodendrocyte differentiation in the adult hypothalamic median eminence
Importantly, the insulinotropic and glucagonostatic actions of GLP-1 are strictly glucose dependent

The mean length of hospital stay (LOS) was 5.7 days (median: 3.9, range: 0.26-45.1)

Some patients may do well with nutrition support and lifestyle changes alone
