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Description

HRT safety considerations: Hormone therapy products both FDA-approved and pharmacy-compounded carry documented risks including blood clots, stroke, breast cancer, and endometrial cancer (in patients with an intact uterus receiving estrogen without adequate progesterone)

Digestion 73 , 142150 (2006)

Nathan DM, Buse JB, Davidson MB, et al

Most patients reach their maximum tolerated dose by week 16

Other clear candidates include patients with BMI 35+ who have tried and failed multiple structured weight loss approaches, patients with obesity plus severe sleep apnea, and patients with a metabolic syndrome phenotype where reducing insulin resistance matters