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Second, activated cAMP can also promote the activation of rap guanine nucleotide exchange Factor 4 (RAPGEF4)
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Indeed, administering GLP-1R agonists into the fourth ventricle in mice decreases food intake and body weight [21, 22], and GLP-1R knockdown in NTS neurons increases food intake [23, 23]
thus, over half of the patients were above a healthy weight [3]
