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Glucagon receptor activation causes more gastrointestinal distress than GIP activation, which partly explains why survodutide has higher discontinuation rates in clinical trials compared to tirzepatide

While individuals appear able to tolerate small increases in exercise relative to their normal routine, larger increases in training load are associated with higher heart rate and persistently lower HRV during GLP treatment[5]

Pan H-C, Chen J-Y, Chen H-Y, Yeh F-Y, Huang TT-M, Sun C-Y, Wang S-I, Wei JC-C, Wu V-C

| Houston Methodist GLP-1 diabetes and weight-loss drug side effects: "Ozempic face" and more | Harvard Health Semaglutide (oral route) - Side effects & dosage | Mayo Clinic 4 Things to Know Before Trying GLP-1s for Weight Loss | Hartford HealthCare | CT Glucagon-Like Peptide-1 Receptor Agonists - StatPearls | NCBI Bookshelf GLP-1 diabetes and weight-loss drug side effects: "Ozempic face" and more | Harvard Health Semaglutide-associated kidney injury | Clinical Kidney Journal | Oxford Academic