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While these results are encouraging, larger trials in broader patient populations are needed to confirm its effects
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In cases of severe or refractory constipation, a short course of a stimulant laxative may be warranted, but this should be used judiciously and under medical supervision
It has long been known that growth differentiation factor 8 (GDF8, also known as myostatin), acting via the activin type II receptors ActRIIA/B in skeletal muscle, is a major negative regulator of muscle mass 7,8,9
