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Saxenda has a longer post-market safety record and is sometimes the right choice for patients who do not tolerate semaglutide well or need a daily routine for clinical reasons

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Liraglutide or insulin glargine treatments improves hepatic fat in obese patients with type 2 diabetes and nonalcoholic fatty liver disease in twenty-six weeks: A randomized placebo-controlled trial

Of note, in STEP 3 intensive behavioral treatment was also administered in both arms, and in STEP 4 all patients were initially assigned to semaglutide 2.4 mg but were randomized 2:1 to semaglutide 2.4 or placebo after 20 weeks 25

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This once-weekly subcutaneous injection was FDA-approved for weight loss in June 2021