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Food and Drug Administration (FDA) and may carry greater risks than FDA-approved treatments

Potential side effects may include gastrointestinal symptoms such as nausea, vomiting, and constipation

Clinical trial evidence consistently shows that GLP-1RA therapy results in significant reductions in fat mass, accompanied by smaller but measurable decreases in lean mass

Eventually, 374 studies were eligible for inclusion in the review (Extended Data Fig

To fully realize the translational potential of GLP-1R agonists, future efforts must address gaps in implementation and integrate real-world evidence into clinical decision-making

[DOI] [PubMed] [Google Scholar] Stopher D