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Functional imaging studies show that GLP-1R agonists blunt neural responses to reward cues in the ventral tegmental area and nucleus accumbens, and retrospective and early prospective data link their use to reduced intake of alcohol and nicotine

Tirzepatide is administered subcutaneously, meaning the medication is injected into the fatty tissue layer beneath the skin

Medications are fulfilled through licensed compounding pharmacies

( Epub 20150618 )

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Neurons immunoreactive to pERK1/2 and c-Fos in medial NTS (bregma 7.32 to 7.76 mm) were counted