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Why Some GLP-1 Medications Cause Less Nausea Once-weekly formulations with gradual dose titration schedules cause less nausea by maintaining stable plasma concentrations and allowing the gut to adapt to delayed gastric emptying

The cleavage of the signal peptide from the pre-proinsulin leads to the formation of pro-insulin, which is subsequently packaged by the Golgi's secretory granules and later cleaved by additional proteins to produce insulin [1]