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The rapidly evolving landscape for CKD-protective therapies in type 2 diabetes currently includes sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA), both of which demonstrate cardiorenal outcome benefits

The best results happen when the medicine is used along with healthy eating and exercise, and people may gain weight back if they stop taking the medicine

Semaglutide and tirzepatide, both once weekly injections, have shown significant reduction in body weight with tolerable side effects

Conclusions/interpretation Tirzepatide improves therapeutic target attainment compared with semaglutide in type 2 diabetes

Nausea affects many semaglutide users, particularly during dose escalation

Trevogrumab + Semaglutide: Phase2 data showed this combination reduced fat while protecting muscle, with patients losing ~11.3% of their body weight