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If your insurance does cover brand-name semaglutide with a reasonable copay (under $100 monthly), staying with brand-name often makes sense

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AE, adverse event

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For the primary endpoint at week 104, the authors report that in evoke, the mean CDR-SB change from baseline was 2.3 (SE 0.1) with semaglutide and 2.3 (0.1) with placebo, with an estimated between-group difference of 0.08 (95% CI 0.35 to 0.20