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In addition to its extensively studied actions in peripheral tissues, studies have evaluated the distribution of GLP-1R in the central nervous system (CNS) of rodents, non-human primates, and humans, showing that it is widely diffused to multiple CNS neurons including neurons of the arcuate nucleus (ARC), which are crucial for the control of energy balance (Fig

Diabet Obes Metab 24:788805

Current research examining the relationship between GLP-1 receptor agonists and breast cancer is reassuring, though still evolving

Front Pharmacol 2018;9:913

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Compare and Contrast The Glucagon-Like Peptide-1 Receptor Agonists (GLP1RAs) StatPearls