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How Prednisone and Tirzepatide Affect Blood Glucose Differently Prednisone is a corticosteroid that increases hepatic glucose production and decreases insulin sensitivity, typically raising blood glucose by 20-50% depending on dose and duration

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Therapeutic considerations Maximal effect seen within 1015 days Adverse effects include allergic reactions, lacrimation, conjunctivitis and salivary gland pain Key prescribing point Iodide is used as a shortterm adjunct , and longterm use should be avoided due to loss of antithyroid efficacy

doi: 10.1007/s00125-009-1515-4 92 CaoCYangSZhouZ

Employers can take this a step further by offering a lifestyle spending account (LSA), which expands flexibility by combining multiple lifestyle and wellness categories in a single, easy-to-manage benefit

The future may involve: Sequencing and Combination: Using agents with complementary mechanisms (e.g., an incretin for weight loss combined with a myostatin inhibitor for lean mass preservation)