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This multi-pronged approach achieves greater reductions in blood sugar levels, as measured by hemoglobin A1c (HbA1c) and fasting plasma glucose, compared to monotherapy

As such, oxyntomodulin exemplifies how endogenous peptides exhibiting multi-receptor activity were disadvantaged by earlier single-target development paradigms

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doi: 10.1001/jama.2015.9676 31 SendaMOgawaSNakoKOkamuraMSakamotoTItoS