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Drucker agreed that these newer drugs do not meaningfully penetrate the brain, but Secher, Rinaman, and others have shown they do meaningfully signal to many regions deep within the brain

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Indeed, germ-free mice exhibit reduced intestinal Glp1r expression and relative GLP-1 resistance (34) associated with elevated levels of circulating GLP-1 (36), consistent with an important role of the microbiota in determining GLP-1 sensitivity

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So fasting in and of itself isnt some miracle method that burns fat