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While tirzepatide's dual GIP/GLP-1 agonism helps counteract some of these hormonal shifts by enhancing satiety signals and reducing appetite, the body's homeostatic mechanisms remain active

You do not start at the maximum dose

Tirzepatide's Dual Mechanism: Why Two Receptors Matter Clinically Tirzepatide activates both GLP-1 and GIP receptors, while semaglutide targets GLP-1 alone

GLP-1 medications like Zepbound help promote beneficial lifestyle changes that can support long-term weight management

Providers may also review body measurements, progress photos, and overall health improvements rather than relying only on weekly scale readings

Your Calorie Intake Has Changed When you first start using tirzepatide, it seems easier to eat less because the medication helps curb your appetite, but gradually, as your body adjusts to the medication, your feelings of hunger might return, causing you to eat more or to snack between meals, consuming more calories without realizing it