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h l , Lean body mass during LI and at follow-up

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Mental stress should be addressed among individuals with obesity, as chronic stress may promote obesity development through the sympathetic nervous system and hypothalamic-pituitary-adrenal axis activation that elevates cortisol levels, interferes with insulin sensitivity, promotes energy storage, and creates food cravings for ultra-processed comfort foods [180] GLP-1s may act both centrally and peripherally to reduce these downstream impacts of chronic stress and obesity and alter food reward pathways in positive ways [124]

Personalized Dosing and Precision Medicine in PCOS Treatment Not all women respond identically to semaglutide

And studies have shown that in people with PCOS who have a higher weight, losing some of it can make a big difference

Some people carry genetic variants associated with heightened GLP-1 pathway activation, potentially increasing the likelihood of rapid appetite loss and metabolic adaptationboth contributors to fatigue