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The primary anti-inflammatory mechanisms include the inhibition of JAK-STAT and NF-B signaling pathways in keratinocytes, enhanced keratinocyte barrier function through increased expression of tight junction proteins, reduced Th17 polarization that drives psoriatic pathology, and reduced oxidative stress through enhanced expression of antioxidant enzymes [131,139,140]

This diversification is also intensifying competition, pushing brands to differentiate through clinically supported ingredients and more sophisticated delivery systems

doi: 10.1210/en.2002-221076

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However, treatment response varies and must be assessed by a doctor

NICE recommends continuing only if specific HbA1c and weight reduction targets are met at 6 months