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This is probably why some people notice improved bloating and appetite regulation before they notice anything on the scale

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Importantly, many of the earlier concerns were derived from animal models or spontaneous adverse event reporting systems, which are limited by their observational nature and lack of control groups (Miyagawa et al., 2015)

These are typically most noticeable in the first few weeks or right after a dose change, and can include nausea, diarrhea, constipation, fatigue, and abdominal pain