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These reports are consistent with the demonstration that GLP1 receptors in the brain are capable of controlling food intake and body weight (Drucker, 2018

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Through its influence on the autonomic nervous system, the ARC modulates blood pressure, feeding behavior, glucose homeostasis, and innate immune responses [57]

Over time, these dietary choices can compound into patterns that adversely impact the gut microbiome, which may influence physiology to negate the beneficial effects of the GLP-1 RAs

Neuroinflammation after cerebral ischemia is the combined result of the activated resident microglia and infiltrating peripheral leukocytes