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Except for ELIXA and EXSCEL [56, 59], all other major CVOTs point towards cardiovascular benefits of GLP-1RAs [53, 54, 61, 63, 66,67,68]

While they help lower blood pressure, they are usually used alongside other treatments as part of a comprehensive plan

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When appetite rebounds abruptly, rebound hunger can increase the likelihood of rapid weight regain

GLP-1RA Therapy as a Chronic Flux Perturbation System-Level Energy Flux Reorganization Under Weight Loss Therapy Most weight-loss interventionsincluding exercise [49], calorie restriction [50], cold exposure [51], and selected antidiabetic agents [10, 52]ultimately increase reliance on FAO, which supplies acetyl-CoA to sustain tricarboxylic acid (TCA) cycle activity and electron transport chain (ETC)coupled adenosine triphosphate (ATP) production

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